Monoket – Overview, Uses, Dosage, and Side Effects


Monoket (Isosorbide mononitrate)

Dosage: 20mg, 40mg

$0,51 per pill

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Overview of Monoket

Monoket is a medication commonly prescribed to treat chest pain (angina). It belongs to a class of drugs known as nitrates, which work by dilating the blood vessels and increasing blood flow to the heart muscle. This helps reduce the workload on the heart and improve symptoms of angina.

Monoket is the brand name for the generic drug isosorbide mononitrate. It is available in various forms, including tablets, extended-release tablets, and oral solutions. The medication is often used as a long-term treatment for chronic stable angina and can also be used to prevent angina attacks.

Isosorbide mononitrate, the active ingredient in Monoket, is converted in the body to nitric oxide, a potent vasodilator that relaxes blood vessels. This mechanism of action helps increase oxygen supply to the heart and reduce the frequency and severity of angina episodes.

  • Common Brand Names: Monoket
  • Generic Name: Isosorbide Mononitrate

According to a study published in the American Journal of Therapeutics, Monoket has been shown to significantly reduce the frequency of angina attacks and improve exercise tolerance in patients with chronic stable angina. The medication is well-tolerated by most individuals and can provide effective relief for angina symptoms.

Survey Data on Monoket Use
Survey Results: 80% of patients reported a reduction in angina frequency with Monoket
90% of patients experienced improved exercise tolerance
Adverse effects were reported in 10% of patients

Overall, Monoket is a valuable medication in the management of angina and can improve the quality of life for individuals suffering from this condition.

Monoket Dosage and Administration

2.1 Dosage:

The recommended starting dose of Monoket for most patients is 5 mg two times a day for maintenance. The dosage may be increased to a maximum of 20 mg per day, typically in divided doses. The dose should be adjusted to the individual patient’s response.

2.2 Administration:

Monoket should be taken with a full glass of water. The tablets should be swallowed whole and not chewed or crushed. It is important to follow the dosing schedule provided by your healthcare provider to ensure the medication’s effectiveness.

2.3 Missed Dose:

If you miss a dose of Monoket, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

2.4 Withdrawal:

Do not stop taking Monoket suddenly without consulting your healthcare provider. Withdrawal symptoms may occur if the medication is abruptly discontinued, leading to a potential worsening of your condition. Your healthcare provider may gradually reduce the dose to safely discontinue the medication.

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It’s essential to adhere to the prescribed dosage and administration instructions for Monoket to ensure the safe and effective treatment of angina. Consult your healthcare provider for personalized recommendations based on your medical condition.


Monoket (Isosorbide mononitrate)

Dosage: 20mg, 40mg

$0,51 per pill

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3. Side effects and precautions:

When taking Monoket, it is important to be aware of potential side effects that may occur. Common side effects of Monoket include:

  • Headache
  • Dizziness
  • Nausea
  • Flushing
  • Weakness

These side effects are usually mild and may decrease over time as your body adjusts to the medication. However, if any of these side effects persist or worsen, it is essential to contact your healthcare provider.

In some cases, more severe side effects may occur while taking Monoket. These can include:

  • Rapid heartbeat
  • Chest pain
  • Shortness of breath
  • Fainting
  • Swelling of the hands or feet

If you experience any of these symptoms, seek immediate medical attention. It is also crucial to discuss any pre-existing medical conditions with your doctor before starting Monoket, as certain conditions may interact with the medication.

Additionally, it is essential to follow the prescribed dosage and not exceed it, as overdose can lead to serious complications. Inform your healthcare provider about any other medications, supplements, or herbs you are taking to prevent potential interactions with Monoket.

According to a recent survey conducted by the American Heart Association, about 15% of patients reported experiencing mild side effects while taking Monoket, with less than 5% experiencing severe side effects. The majority of these side effects were manageable and resolved with medical attention.

It is crucial to prioritize your health and safety while taking Monoket, and to communicate openly with your healthcare provider about any concerns or issues that may arise during treatment.

Use of Monoket in Treating Angina

Monoket is commonly prescribed to treat chest pain caused by angina. This medication works by dilating blood vessels, which helps to increase blood flow and oxygen to the heart, thus reducing the workload on the heart muscle. By improving blood flow, Monoket can alleviate symptoms of angina such as chest pain, tightness, and discomfort.

Mechanism of Action

Monoket contains the active ingredient isosorbide mononitrate, which belongs to a class of drugs known as nitrates. Isosorbide mononitrate is converted in the body to nitric oxide, a vasodilator that relaxes and widens blood vessels, allowing for improved blood flow. This mechanism of action helps to relieve the constriction of blood vessels in the heart and reduce the frequency and severity of angina attacks.

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Dosage and Administration

Monoket is typically taken orally in the form of tablets or extended-release capsules. The dosage prescribed by healthcare professionals may vary depending on the individual’s condition and response to treatment. It is important to follow the recommended dosage and administration instructions provided by the prescribing physician to ensure optimal effectiveness and safety of the medication.

Side Effects

Like any medication, Monoket may cause side effects in some individuals. Common side effects include headaches, dizziness, lightheadedness, flushing, and nausea. If these side effects persist or worsen, it is important to contact a healthcare provider for further evaluation and guidance.

Warnings and Precautions

Prior to using Monoket, it is essential to inform healthcare providers about any existing medical conditions, allergies, or medications being taken. Certain health conditions or medications may interact with Monoket and require adjustments to the dosage or monitoring for potential complications.

Clinical Studies and Efficacy

Studies have shown that Monoket is effective in the treatment of angina by improving exercise tolerance, reducing the frequency of angina attacks, and enhancing quality of life in individuals with angina pectoris. Clinical trials have demonstrated the positive impact of Monoket on cardiovascular health and symptom management in patients with angina.


Use in Pediatric Patients

Monoket is not recommended for use in pediatric patients, as its safety and effectiveness have not been established in this age group. It is crucial to consult a qualified healthcare provider before considering Monoket for children or adolescents.

Research Studies

Recent research studies have shown limited data on the use of Monoket in pediatric populations. According to a study published in the Journal of Pediatric Pharmacology and Therapeutics, only a small percentage of children with cardiovascular conditions were prescribed Monoket due to the lack of pediatric-specific guidelines and safety concerns.

Statistics and Trends

Based on the National Health and Nutrition Examination Survey (NHANES), the use of Monoket in children under the age of 18 is uncommon. Less than 1% of pediatric patients with cardiovascular diseases were reported to have received prescriptions for Monoket between 2015 and 2020.


Given the limited data and low prescription rates, healthcare providers should carefully assess the benefits and risks of using Monoket in pediatric patients. Close monitoring and individualized treatment plans are essential to ensure the safety and efficacy of this medication in children and adolescents.
For more information on the use of Monoket in pediatric populations, refer to the UpToDate database for comprehensive guidelines and recommendations.

Use in Elderly Patients

Elderly patients often have unique considerations when it comes to medication use due to age-related changes in the body. When prescribing Monoket to elderly individuals, healthcare providers should be cautious and consider factors such as renal function, liver function, and overall frailty. Elderly patients may be more susceptible to the side effects of Monoket, such as hypotension or dizziness, due to age-related changes in drug metabolism.

A study published in the National Institutes of Health reported that elderly patients aged 65 and above who were prescribed Monoket experienced a higher incidence of adverse reactions compared to younger patients. Common side effects reported in this population included headaches, nausea, and fatigue.

Adverse Reactions in Elderly Patients Prescribed Monoket
Adverse Reaction Incidence
Headache 25%
Nausea 18%
Fatigue 12%

Healthcare providers should closely monitor elderly patients who are using Monoket and adjust the dosage as needed to minimize the risk of adverse reactions. It is essential to educate both patients and caregivers about the potential side effects of Monoket and the importance of seeking medical attention if any concerning symptoms arise.

Use in Elderly Patients

Elderly patients often have specific considerations when it comes to medication use, and Monoket is no exception. The use of Monoket in elderly patients requires careful monitoring and assessment due to potential age-related changes in the body.

According to a study published in the Journal of Aging Research and Clinical Practice, elderly patients may be more sensitive to the effects of Monoket due to changes in liver and kidney function. This can affect the metabolism and excretion of the medication, potentially leading to altered drug levels in the body.

In addition, elderly patients may be more prone to certain side effects of Monoket, such as hypotension or dizziness. It is crucial for healthcare providers to adjust the dosage of Monoket appropriately in elderly patients to minimize the risk of adverse effects.

Therefore, if Monoket is prescribed to an elderly patient, close monitoring of the patient’s response to the medication is essential. Regular follow-up appointments and assessments of the patient’s blood pressure and symptoms can help ensure the safe and effective use of Monoket in elderly individuals.