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Health: Soon An Anti-Aging Pill?

I would like to die young as late as possible,” wrote the novelist Marcel Prevost. This myth of eternal youth may be on the verge of becoming a reality. Last February, US researchers announced that they have been able to extend their lifespan by more than 20%of mice by eliminating part of their senescent cells – end-of-life cells, the number of which increases with age and releases toxic substances. Also, these rodents, cleaned of their “old cells,” were also healthier and developed fewer cancers. From there to imagine that we can tomorrow remove senescent cells in humans and delay aging, there is only one step! Even if the effects in animals are not always reproducible in humans. “This is a promising result because it shows that targeting a single cell subpopulation can delay the aging of an entire organism,” says Gilles Charvin, a CNRS researcher at the Institute of Genetics and Molecular Biology. And cell at the University of Strasbourg. The lead author of the study,

An Antidiabetic Agent Tested For Its Anti-Aging Effects

Another blow in 2015, the US Drug Administration (FDA) has authorized for the first time a clinical trial that will assess the effects in humans of a molecule, not on a given pathology, but on different aging-related diseases (cancer, diabetes, cardiovascular disease and cognitive impairment) as well as longevity. This is metformin, a known drug, used for sixty years against type 2 diabetes and has suspected anti-aging effects. If this test is conclusive, its leader NirBarzilai, director of the Albert Einstein College of Medicine in New York, hopes to have the FDA recognize aging as a new therapeutic indication. This would be a real turning point and would open the door to the development of other treatments by the pharmaceutical industry but also by new players like Calico, the Google subsidiary created in 2013 and dedicated to this quest for a “pill of youth.” The interests at stake are enormous and powerful lobbying is at work in the United States to get the green light from the FDA. “We can imagine that the first molecule” anti-aging “can be marketed in a decade,” says Hugo Aguilaniu, director of research at the CNRS and the Institute of Functional Genomics of Lyon, specialist longevity mechanisms. The interests at stake are enormous and powerful lobbying is at work in the United States to get the green light from the FDA. “We can imagine that the first molecule” anti-aging “can be marketed in a decade,” says Hugo Aguilaniu, director of research at the CNRS and the Institute of Functional Genomics of Lyon, specialist longevity mechanisms. The interests at stake are enormous and powerful lobbying is at work in the United States to get the green light from the FDA. “We can imagine that the first molecule” anti-aging “can be marketed in a decade,” says Hugo Aguilaniu, director of research at the CNRS and the Institute of Functional Genomics of Lyon, specialist longevity mechanisms.

Caloric Restriction: A Track for Longevity

If there is so much boiling around the promise of this anti-aging pill, it’s that science has come a long way in recent years. What was until recently considered impossible – for example, extending the lifespan of animal models by modifying a gene or injecting a molecule – is now possible. Several routes have been discovered to increase longevity. One of the best known is a caloric restriction . of regime slow in calories have indeed raised the lifespan of worms, flies and laboratory mice. “It also reduces the risk of cancer in rodents and primates by 70%,” says Hugo Aguilaniu. But this approach has deleterious effects in reducing fertility and healing ability. Other recent, rather spectacular studies have demonstrated the rejuvenating effect of blood transfusion of “young” mice in older mice and in particular the role of specific molecules circulating in the blood. There is also research on telomeres, located at the ends of our chromosomes and whose wear causes the degradation of our cells, as well as on free radicals, sources of oxidative stress.

All this work will potentially lead to the development of drugs that can delay specific effects of aging in humans and extend life expectancy. As a reminder, in 2015, life expectancy in France was 85 years for women and 78.9 years for men. Some think that we will all be able to live tomorrow until 120 years or beyond, for the most optimistic (see box)! These perspectives, however, raise ethical and economic issues. While waiting for the arrival of the miracle pills, it is undoubtedly by leading a healthy and active life that one can give oneself the best chances of dying young and as late as possible.

Stop Aging: The Quest for Amortization

Proponents of transhumanism, a current born in the United States that advocates the use of new technologies to improve human life, think we can live beyond 120 years, up to 500 years or even 1000 years (!). “Slowing down the degradation associated with aging could be possible in twenty to thirty years because we are progressing in many areas (gene therapy, nanotechnology, microsurgery), said Didier Coeurnelle, spokesman of the French Transhumanist Association (AFT-Technoprog). We can live longer in good health and therefore die later. In the longer term, it will be possible to stop aging. The hope is to reach, not immortality, but the amortization (a life without limit) “. This opinion is however far from being shared by all researchers. “Scientifically, there is nothing to say that we can all live much more than 120 years, says Patrick Gaudray, geneticist, director of research at the CNRS and member of the National Consultative Ethics Committee (CCNE). The so-called quest for immortality is for my fantasy and illusion. “

Healthy Diet and Physical Exercise To Combat Obesity

The practice of exercise and the adoption of healthy diets like targeted ketogenic diet are vital in reducing overweight and obesity, a problem that increasingly affects more children and adults and concerns the experts, as seen in recently published information.

The European Parliament warns about the increase in obesity among the population

The European Parliament advises in a recent report to intensify education and promote healthy diets and physical exercise among the community – and especially in schools to alleviate what is already considered a chronic disease: overweight and obesity. According to the European Parliament, it is an epidemic that currently affects in Europe 27% of men, 38% of women and almost five million children.

Action measures of the European Commission

In addition to publishing White Paper on nutrition and physical exercise, the European Commission suggests in its report ten measures of action, among which stresses the need to prevent and treat obesity in all ages, also intensifying dietetics education in schools, where sport should be promoted and healthy diets consumed. It is also considered a priority to establish a system of clear labeling of food and to control the advertising claims on the packaging, which tend to weigh more on the consumer’s choice than the food values of the product.

Increase in cases of hypertensive children

Hypertension is no longer a disease reserved for adults. There are more and more hypertensive children from 10 years old, as the Valencian Society of Arterial Hypertension and Vascular Risk shows. Bad lifestyles, such as inadequate nutrition and lack of physical exercise, are to blame for hypertension in children, an unusual disease until ten years ago in people under 35 years of age. The detection and treatment of this pathology involve different specialists – primary care physicians, cardiologists, nephrologists, endocrinologists, and pharmacists – while making more information and education on health necessary for prevention.

Nutrition and school performance

Students who skip breakfast make more mistakes when solving problem exercises. Experts at the University of Wales believe that lunch increases the blood glucose level and also activates a brain transmitter related to memory. Vitamin B1, present in processed cereal-based foods – such as wholemeal or enriched bread – is one of the leading producers of this transmitter.

Experts recommend that breakfast provide 25% of the energy and nutrients needed for the rest of the day. According to a study carried out by the Spanish Society of Dietetics and Food Sciences (SEDCA), 22% of Spanish schoolchildren only drink a glass of milk before going to school. The same study argues that including breakfast cereals and fruit not only improves school performance but also helps prevent childhood obesity.

Benefits of physical activity and healthy eating

Eating nutritious and balanced foods combined with daily physical activity is the best way to respond to the old and well-known saying “prevention is better than cure.” Even finding something as simple as a keto diet plan for beginners will help you east better.  In general, there is a tendency to relate diet and exercise with a stylized and slender figure; however, the benefits of balanced diet and exercise go beyond pure beauty, and reach the field of health, through the prevention of heart disease, cancer, and other conditions.